In an OVA-induced murine model of allergic asthma, IGFBP-3 expression was decreased [32], and levels of HIF-1α and HIF-2α in nuclear protein extracts from lung tissues were increased at 48 h after OVA inhalation compared to levels measured 48 h after saline inhalation [33]. The gene discussed is EPAS1; the disease is allergic asthma.