Immunoblot analysis showed that PDGF neutralization inhibited mesenchymalization in GBM-associated ECs, as evidenced by that 5-day incubation with anti-PDGF-AA antibody, anti-PDGF-BB antibody, alone or combined, abolished FSP-1 and N-cadherin expression (Fig. 5a). The gene discussed is CDH2; the disease is glioblastoma.