APP and early-onset autosomal dominant Alzheimer disease: Furthermore, an elucidation of the substrate-γ-secretase interaction will assist in developing disease specific therapeutics that target APP processing in Alzheimer’s disease and Notch processing in certain cancers17, cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL)19 and acne inversa20.