TMPRSS2 and Familial prostate cancer: In addition to somatic mutations, somatic copy number alterations (SCNA) are recurrently seen in prostate cancer, including the amplification of chromosome 7 and 8q (affecting the MYC locus), and the focal deletion of chromosome 1q42, 3p13 (FOXP1), 4p15, 6q12–22 (MAP3K7), 8p, 13q, 16q, 17p (TP53), 18q12, and 21q22.3 (TMPRSS2-ERG fusion)5,7,12,13.