FKRP and neuromuscular disease caused by qualitative or quantitative defects of alpha-dystroglycan: One most common dystroglycanopathy caused by mutations in the fukutin-related protein (FKRP) gene manifests a wide range of disease severity from mild limb girdle muscular dystrophy (LGMD) 2I to severe congenital muscular dystrophy (CMD), Walker–Warburg syndrome, and muscle–eye–brain disease8–10.