The cellular uptake results suggested the angiopep-2 only targeted the endothelial cells while IP10-EGFRvIIIscFv fusion proteins only targeted the glioblastoma cells; further, IP10 could facilitate transendothelial chemotaxis required for recruitment of CTLs to the target glioblastoma cells. The gene discussed is CXCL10; the disease is glioblastoma.