SLURP1 and infection: Interestingly, infection of MDMs with myristoylation-deficient MA mutant (G2A) that prevents stable membrane association of HIV-1 Gag13 attenuated viral icRNA-induced MDM activation (Fig. 4b, c), while none of the other well-characterized MA membrane-targeting domain mutants or those that potentially alter Gag assembly structure or icRNA–Gag association prevented MDM activation (Supplementary Fig. 4b, c).