In addition, in 1 SMCI patient, who has not yet develop AD and who had received multiple TBIs during his Ukrainian military service, we also observed distinct S100A9 and Aβ plaques, which were not cross-reactive with both S100A9 and Aβ antibodies, as well as plaques containing both antigens (Fig. 4K,L). The gene discussed is S100A9; the disease is Alzheimer disease.