In this study, statistical analysis proved that elevated β2-M, rash/pruritus, PS ≥2, age ≥60 years and ENSs >1 were independent prognostic factors for AITL while β2-M and rash/pruritus were not used in IPI or PIT prognostic model. The gene discussed is B2M; the disease is angioimmunoblastic T-cell lymphoma.