This phase II clinical study, entitled “ERC1671/GM-CSF/Cyclophosphamide for the Treatment of Glioblastoma Multiforme” (NCT01903330), is designed to show the anti-tumor efficacy of Gliovac plus GM-CSF plus Cy with bevacizumab (bvz), as compared to placebo injection (instead of Gliovac/GM-CSF) plus placebo pill (instead of Cy) with bvz, in patients with recurrent grade IV malignant gliomas, including GBM. This evidence concerns the gene CSF2 and glioblastoma.