However, we did not find that the clinicopathological variables including age, stage, histologic type, histologic grade, tumor size, squamous cell carcinoma antigen (SCC) level, carcinoembryonic antigen (CEA) level, combined chemotherapy, high expression of SOX2, or high expression of ALDH1A1 displayed a statistically significant difference between the two groups (Table 1). This evidence concerns the gene SOX2 and neoplasm.