CDKN2A and neoplasm: Moreover, low expression of P16INK4A in the tumor was a significantly poor prognosis factor for OS (HRs = 1.818; 95% CIs, 1.111–2.976) and DFS (HRs = 1.941; 95% CIs, 1.057–3.559) for the patients treated with radiotherapy in our study (Figure 2A,B).