A similar trend of activity was reported when pancreatic cancer cell lines [65] and human brain glioblastoma multi form cells [66] were incubated with BITC, and glioma cells with PEITC [53], where the PEITC was found to significantly potentiate the induction of cytotoxicity and apoptosis in glioma cells through the agonistic effect of the tumor necrosis factor-related apoptosis-induced ligand (TRAIL). Here, TNFSF10 is linked to central nervous system cancer.