Holo-Tf displaces the interaction of hereditary hemochromatosis protein (HFE)-TfR1 and stabilizes the association of HFE-TfR2 with membrane-anchored hemojuvelin (mHJV), forming a complex of HFE/TfR2/HJV which is dispensable for hepcidin transcription [10,11,28]. The gene discussed is TFR2; the disease is hemochromatosis.