MMP2 and neoplasm: TRAF6 was also associated to regulate intramembrane proteolytic cleavage of TGF-β type I receptor in cancer cells, where the intracellular domain (ICD) of the TGF-β type I receptor enters into the nucleus, thereby activating genes involved in tumor cell invasiveness, including matrix metalloproteinase2 (MMP2) and Snail [58].