In the progressive fibrotic kidney disease model by repeated injection of anti-mesangial serum, the glomerular expression of TGF-β1 mRNA and TGF-β1 protein remained elevated, which was associated with glomerulosclerosis and tubulointerstitial fibrosis with marked deposition of collagens type I and III [12]. The gene discussed is TGFB1; the disease is kidney disorder.