TGFB1 and focal segmental glomerulosclerosis: Conversely, kidneys from diabetic nephropathy, Immunoglobulin A (IgA) nephropathy, focal and segmental glomerulosclerosis (FSGS), crescentic glomerulonephritis, and lupus nephritis showed significantly increased expression of all three TGF-β isoforms in glomeruli and tubulointerstitium [7].