Thus, significant increases were noted in the frequencies of plasmablasts and plasma cells from dengue patients that expressed CCR9 (homing to the small intestine), CCR7 and CD62L (lymph node homing), CXCR4 (bone marrow homing) and markers such as CXCR3 and CCR2 that are associated with homing to inflammatory sites. This evidence concerns the gene CXCR4 and dengue disease.