LncRNA HOTAIR (HOX transcript antisense RNA) regulated HIF-1α (hypoxia inducible factor 1 subunit alpha)/AXL (AXL receptor tyrosine kinase) signaling and promoted tumorigenesis through acting as a ceRNA of miR-217 in renal cell carcinoma [26]. This evidence concerns the gene NTRK1 and hereditary clear cell renal cell carcinoma.