Subsequently, the Western blot assay showed that upregulation of RP11-79H23.3 significantly decreased the levels of p-PI3K, p-AKT, and p-GSK3β in BC cells as well as increased the expression of PTEN, whereas si-RP11-79H23.3 led to the activation of the PI3K/AKT pathway. This evidence concerns the gene AKT1 and breast cancer.