A recent study explored the associations among clinical symptoms, regional tau and Aβ deposition assessed by PET imaging with [11C]PBB3 and [11C]Pittsburgh compound-B (PiB) in AD, MCI due to AD and healthy individuals, and identified significant positive correlation between tau accumulation with Aβ pathology in all subjects, as well as significant correlation with tau burden in the healthy individuals. This evidence concerns the gene MAPT and Alzheimer disease.