MAPT and Alzheimer disease: Using non-selective γ-secretase inhibitors, potential inhibition of Aβ and subsequent decline in moderate AD were achieved in Phase III clinical trials [208,209].Ittner et al. has previously demonstrated a unique mechanism through which the phosphorylation of Threonine 205, a specific residue of tau that is of significance for protection against Aβ induced excitotoxicity [210].