Recently, Salinas-Sánchez et al. conducted a prospective, longitudinal cohort study of 50 patients diagnosed with ccRCC and analyzed VHL mutations and hypermethylation as well as VHL, HIF1-α, VEGF, ERK1/2 and ERK5 protein expression [31]. The gene discussed is MAPK3; the disease is nonpapillary renal cell carcinoma.