Our data showed that 3-O-trans-p-coumaroyltormentic acid induced c-Myc protein degradation through the ubiquitin-independent pathway (Figure 5D and Figure S14), and suggests that the proliferation, growth, and survival of breast cancer stem cells are critically dependent on c-Myc expression and that targeting c-Myc pathways may significantly improve breast tumor therapy. This evidence concerns the gene MYC and breast neoplasm.