PACS2 and neoplasm: Moreover, some proteins within the MAMs have been proposed as potential regulators of tumor cell metabolism, for instance, TMX1 is related with glycolysis and oxidative phosphorylation balance [80], mitofusin-2 as an important regulator on MAMs contact has been associated to pro-apoptotic and anti-proliferative signaling [81], and PACS-2 proposed as a tumor suppressor [82].