For instance, in one study the effects of UGCG on multidrug resistance protein 1 (MDR1) levels was characterized, which concluded that UGCG, specifically Gb3 and Gb4 up-regulates expression of MDR1 through β-catenin signaling, granting doxorubicin and paclitaxel resistance to murine breast cancer cells [159]. The gene discussed is UGCG; the disease is breast carcinoma.