Because the virally-delivered CXCR4 antagonist blocks the CXCL12/CXCR4 axis involved in tumor progression via enhanced local immunosuppression [15,16,42], we next investigated whether inhibition of NSX2 tumor after targeting the CXCL12/CXCR4-signaling axis through an oncolytic virus would also be related to changes within the TME (Figure 3). The gene discussed is CXCL12; the disease is neoplasm.