IGF1R and hypertensive disorder: Exercise training prevented hypertension-induced cardiac Fas-dependent and mitochondria-dependent apoptotic pathways via enhanced cardiac insulin-like growth factor 1 receptor (IGFI-R)/phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) and Bcl-2-family-associated prosurvival pathways in hypertension [44].