DNASE1 and cystic fibrosis: Despite this, other valuable gelsolin-mediated features, including binding of bacterial endotoxins, prevention of inactivation of antimicrobial peptides [108], and reversal of the stimulatory effect of actin on P. aeruginosa biofilm production in CF lungs [126], indicate that further clinical studies on use of exogenous gelsolin in the treatment of chronic infections that occur in cystic fibrosis airways, alone or in combination with other depolymerizing agents (e.g., Pulmozyme; inhaled recombinant human deoxyribonuclease 1), are justified (Figure 4) [125].