Along with the studies showing considerable prognostic value of gelsolin in predicting clinical outcomes in patients with acute brain injuries, including intracerebral hemorrhage [68], ischemic stroke [133], and traumatic brain injury [40], a number of studies demonstrate the usefulness of low levels of pGSN as an independent predictor of poor outcome after aneurysmal subarachnoid hemorrhage (SAH). The gene discussed is GSN; the disease is ischemic stroke.