GSN and cancer: Although gelsolin was found to be downregulated in gastric [150], breast [156], colorectal [152,157], lung [158], prostate [159], kidney [160], ovarian [161], and pancreatic [154] cancers, there is also evidence that upregulation of gelsolin in tumors may promote aggressive behavior, and increased expression of this protein in certain tumors correlates with poor prognosis and therapy-resistance.