The other important observation from the same cohort of HAD patients was increased expression of gelsolin in HAD sera, which was undetected previously using a different analytical method and upregulated gelsolin levels in HIV-1-infected and HIV-/HCV-coinfected patients, induced likely by increased viral infection, which highlights the importance of the analytical method in evaluation of potential biomarkers [60,121]. The gene discussed is GSN; the disease is viral infectious disease.