Apart from the actin scavenging properties of plasma gelsolin, one of the most important features of extracellular gelsolin for its protective role in sepsis is the ability of pGSN to selectively interact with bacterial wall products (i.e., LPS from gram-negative, and LTA from gram-positive bacteria), effectively modulating cellular response and diminishing the inflammatory reaction of the host. Here, GSN is linked to Sepsis.