Several conditions are required for a T cell epitope to be immunogenic: (1) the protein must be present in sufficient quantities within the tumor cells, (2) the protein must be processed so that the peptide remains intact for presentation by the major histocompatibility complex (MHC), (3) the peptide needs to bind to the MHC with sufficient strength and for a sufficient amount of time, and (4) the peptide should be recognized as foreign. The gene discussed is HLA-C; the disease is neoplasm.