IFNA1 and Zika virus infectious disease: In this way, ZIKV infection induces IFN signaling pathways and further activates cytoplasmic retinoic acid inducible gene 1 protein (RIG1)-like receptors (RLRs) and several type I and III IFN-stimulated genes, driving to the subsequent activation of the Janus kinase (JAK)/STAT innate immune pathway that confer resistance to ZIKV infection [54].