TP53 and breast cancer: Ever since, specific mutation hotspots in some genes, such as PIK3CA, TERT, FGFR3, RAS and TP53, have been targeted to detect mutations in ctDNA from BC patients, which has led to the discovery of associations between the presence of ctDNA mutations in these genes in urine as well as plasma samples and disease recurrence and progression [102,103,104].