In this way, Silvers reported that EVs collected from urine of six BC patients (pT1-pT3) showed, at least, a fifteen fold enrichment in the protein levels of β-Hexosaminidase (HEXB), S100A4 and Staphylococcal nuclease and tumour domain containing 1 (SND1) compared to the urinary protein levels of six healthy volunteers (p < 0.05) [235]. Here, S100A4 is linked to breast cancer.