The incompetence of the tumor microenvironment to be enriched by TAMs due to RKIP-mediated CCL5 reduction was translated into a decreased tumor cell invasiveness and secretion of pro-metastatic factors, including tumor necrosis factor receptor 2 (TNFR2) and progranulin (PRGN), by TAMs [160]. This evidence concerns the gene TNFRSF1B and neoplasm.