The direct suppressive effects of RKIP ectopic induction or Snail silencing in the expression of the downstream anti-apoptotic proteins of the Bcl-2 family, as well as in the type II apoptotic pathway activation, support the opposing roles of RKIP and the NF-κB/Snail module in the regulation of tumor chemo/immuno-resistance [26,126]. Here, NFKB1 is linked to neoplasm.