We and others have reported that small molecules such as NPI-0052 and DETA/NO, or immunomodulating agents including αnti-CD20 and αnti-CD80 antibodies, are able to sensitize various resistant cancer cell lines to both chemo- and TNF-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis, through NF-ΚB and Snail signaling inhibition and RKIP induction [26,74,123,126,138,165,166]. The gene discussed is TNFSF10; the disease is cancer.