Cytokine/growth factor-activated Src and STAT3 have been linked with promotion of EMT, migration, invasion, and angiogenesis in cancer cells [93,94,95,97,141,142], through induction of STAT3 downstream metastasis-associated proteins, including mucin 1 (Muc1), VEGF, and CXCR4, and by microtubule stabilization [143]. This evidence concerns the gene STAT3 and cancer.