PTEN and neoplasm: As PTEN is an endogenous inhibitor of the PI3K/Akt signaling [214] and it is transcriptionally repressed by Snail [215], we suggest that RKIP-mediated NF-κB/YY1/Snail inhibition may trigger Akt inactivation by PTEN induction, leading to subsequent reversal of the resistant tumor phenotype.