NF-κB activity promotes tumor resistance to conventional chemotherapy and immuno-mediated cytotoxicity mainly by inducing the expression of B-cell lymphoma 2 (Bcl-2)-related anti-apoptotic gene products, cellular FLICE (FADD-like IL-1β-converting enzyme)-inhibitory protein (c-FLIP) and inhibitor of apoptosis proteins 1/2 c-IAP1/2 and X-linked inhibitor of apoptosis protein (XIAP), as well as by regulating death receptor expression [90,91]. This evidence concerns the gene BCL2 and neoplasm.