HMGA2 is a chromatin remodeling factor that promotes EMT and invasion by upregulating Snail, Slug, and Twist [14,18,110], while BACH1 is a transcription factor involved in bone metastasis of breast cancer by upregulating vital metastatic genes such as chemokine receptor type 4 (CXCR4) and matrix metalloproteinase 1 (MMP-1) [111]. Here, MMP1 is linked to breast carcinoma.