Notably in melanoma RKIP was found to inhibit melanoma differentiation antigen-9 (MDA-9)/syntenin-mediated tumor migration and metastasis through physical association with MDA-9, that disturbs the assembly of stable c-Src/focal adhesion kinase (FAK) signaling complexes, which is essential for the activation of NF-κB and MMPs [129]. This evidence concerns the gene PEBP1 and melanoma.