In contrast to SDC2, miR-200b, LOX, and miR29 that positively regulate breast cancer initiation, EMT or invasion [113,114], the expression of the TET1 demethylase and its downstream target HOXA9 have been shown to suppress invasion, intravasation, extravasation, and metastasis of triple-negative breast cancer (TNBC) cell lines in vitro and in vivo [14,112]. This evidence concerns the gene LOX and breast carcinoma.