The de-repression of death receptor transcription by RKIP-promoting drugs (NPI-0052, DETA/NO, etc.), or RKIP overexpression abrogates tumor resistance to TRAIL and Fas-ligand (FasL)-mediated apoptosis [26,31,34,74,80,139,179,180,181,182,183,184,185]. The gene discussed is FASLG; the disease is neoplasm.