Low RKIP expression or its loss associates with the onset and development of gastric cancers and its ability to invade and metastasize [57,221], as well as with recurrence in esophageal squamous cell carcinoma (ESCC) [222], malignant progression in hepatic fibrosis [223], and poor survival in gastric cancer [224,225]. This evidence concerns the gene PEBP1 and esophageal squamous cell carcinoma.