STK33 and neoplasm: Among the 12 candidates, STK33 is certainly the gene most studied in cancer, which is probably the case because Scholl et al. reported that STK33 is indispensable for the survival of several KRAS-mutant tumor cells due to STK33-dependent suppression of mitochondrial apoptosis [154]; however, this same finding was not confirmed by other independent groups [155,156].