Noteworthy, apart from many functional similarities between YAvns and natural Avns, we found that YAvns were more effective than the natural compounds tested in inhibiting colon cancer cell migration and reverting major molecular features of the EMT process, including the downregulation of E-cadherin mRNA and protein levels, and the upregulation of the transcription factors Snail1 and LEF-1, suggesting that the peculiar molecular structure of YAvns endows them with an enhanced potential capacity to limit EMT-mediated cancer progression and metastasis. This evidence concerns the gene LEF1 and cancer.