Our experimental outcomes showed that YAvns were as effective as natural Avns in inhibiting colon cancer cell proliferation, clonogenicity and anchorage-independent growth, and enhancing cell adhesion, as well as in increasing the expression of major cell cycle regulators, such as p21, p27 and p53 proteins, suggesting that YAvns and natural Avns share a common capacity in preventing and reversing key events involved in cancer development and progression. Here, TP53 is linked to malignant colon neoplasm.