TP53 and lung cancer: Therefore, in order to verify the previous findings on the cytotoxicity of P. cocos toward human lung cancer cells [17] and determine its relationship to the p53 status of the cells, we prepared an EtOH extract of the sclerotia of P. cocos, and examined its effects on cell viability in four human lung adenocarcinoma cell lines accompanying different p53 statuses: A549 (p53-wild-type), H1264 (p53-mutated), H1299 (p53-null), and Calu-6 (p53-null) [23,24] (Figure 1 and Table 1).