B-mode ultrasound of the eye could thus complement visual evoked potentials [6,20] and optical coherence tomography [21–24], in the assessment of the visual pathway and could thus help to investigate afferent anterior visual pathway damage in patients with inflammatory conditions, such as CIS, MS, NMOSD or MOG antibody associated encephalomyelitis [25–29]. This evidence concerns the gene MOG and encephalomyelitis.