MMP19 and IgA glomerulonephritis: From IgA nephropathy data, performance of the regression model with time-averaged proteinuria to estimate the deterioration in eGFR slope was rapidly improved during 2–3 years after RASi treatment and then plateaued over the remaining time frames, and the author suggested that 24- and 36-month observations for deteriorating renal function would be suitable because the outcome was predicted 50% sooner at a loss of only 25% accuracy compared with the longer observation period [10].