Compared with GLP-1RA, all agents were associated with a lower risk of hypoglycemia, except Met [OR, 0.58 (95% CI: 0.29 to 1.18)] and basal insulin [OR, 0.76 (95% CI: 0.27 to 2.17)], which appeared to have no significant effects on the risk of hypoglycemia (Table 2 and Fig 3). This evidence concerns the gene INS and Hypoglycemia.