Within a curated brain-specific PPIN (see Methods, [40]), we inspected first order interacting proteins with potentially deleterious mutations or exon losses (see Table 6) and found a few interesting hits, including SPTAN1 that interacts directly with SHANK1; SPTAN1 encodes alpha-II spectrin and is known to be associated with epilepsy [56,57]. This evidence concerns the gene SHANK1 and epilepsy.