IFN- γ levels applied in a high burden setting for TB [7], presented a better performance than ADA and Xpert MTB/RIF®, and based on a cut-off point of 107.7 pg/mL provided a Se of 92.5% and a Sp of 95.9% versus a 79% sensitive and 92.7% specific ADA (clinical cut point of 30 IU/L) and a 22.5% sensitive and 98% specific Xpert MTB/RIF®, which, in our sample, showed a positivity of 14.3% (S1 Table). The gene discussed is ADA; the disease is tuberculosis.