However, somewhat paradoxically, GPR55 expression has been shown to positively correlate with obesity in human adipose tissue, and, although the effects of LPI on insulin signaling in human fat were not studied, LPI induced expression of lipogenic genes when incubated ex vivo with visceral, but not subcutaneous, fat explants (29). This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.