AR and neuromuscular disease: These mice carry the human AR transgene with abnormally expanded polyglutamine tract in the AR (AR97Q) and develop signs of neuromuscular disease by 10 weeks of age (weight loss, hunched back, and muscle atrophy).11 Lumbar spinal cord and quadriceps muscle were harvested at 2, 4, 8 and 12 weeks after administration for miRNA quantification, biochemical assay and immunohistochemistry (Figure 1).