Similarly, Giovacchini et al. reported on a study of 195 men with rising PSA during androgen deprivation therapy for BCR after radical prostatectomy, in which men with a positive 11C-choline PET/CT scan were more than twice as likely to die of prostate cancer than men with a negative scan, even after adjusting for other prognostic factors in a multivariable analysis (Giovacchini et al. 2014). This evidence concerns the gene KLK3 and prostate cancer.