In GSE14520 profile, HCC patients had advanced TNM staging in CYP2A6 and CYP2C8 low expression groups compared to those in CYP2A6 and CYP2C8 high expression groups (P = 0.005 and P = 0.032, respectively, Table 2). This evidence concerns the gene CYP2C8 and hepatocellular carcinoma.