Common genetic defects leading to severe HTG include lipoprotein lipase deficiency, LPL gene mutation, and Apolipoprotein C II deficiency in addition to mutations in GPIHBP1 (glycosylphosphatidylinositol-anchored high-density lipoprotein binding protein 1), LMF1, and other genes involved in lipoprotein generation and metabolism [9]. This evidence concerns the gene GPIHBP1 and hyperinsulinemic hypoglycemia, familial, 4.