In a recent meta-analysis evaluating the effects of insulin therapy on outcomes of severe acute pancreatitis, intensive insulin therapy was found to lower APACHE II score after 72 hours of treatment (weighted mean difference (WMD) = -3.80, 95% CI [-4.88,2.72], p < 0.00001) and shorten the length of hospitalization (WMD = -12.13, 95% CI [-15.48,8.78], p < 0.00001); however, only 3 studies with small sample size were included in this meta-analysis [35]. The gene discussed is INS; the disease is acute pancreatitis.