IGF1R and hepatocellular carcinoma: Although 122-exo could alter the expression of target genes, such as those encoding cyclin G1 (CCNG1), disintegrin and metalloprotease 10 (ADAM10), and insulin-like growth factor receptor 1 (IGF1R) in hepatoma cells, 122-exo alone failed to inhibit tumor growth in a HepG2 cell xenograft model in nude mice [28].