Takahashi et al. attribute the TGFβ-induced tumor cells dedifferentiation and acquired chemoresistance to the deregulated linc-ROR in HepG2 cells, whereas sorafenib exposure increases linc-ROR in HCC cells, HCC-derived exosomes, and exosome-treated recipient cells [26]. This evidence concerns the gene TGFB1 and hepatocellular carcinoma.