IGF1R and polycystic ovary syndrome: According to our hypothesis a potential pathogenic mechanism of PCOS could be that androgen-driven overexpression of IGF1R, would make the oocyte hypersensitive to growth factors such as IGF2, which is found in a high level, and thus trigger hyperactivity in the PI3K/PTEN/Akt pathway, resulting in a hyperactivation of primordial follicles.