MAPT and Alzheimer disease: Abnormal tau aggregation occurs not only in the AD brain, but also in a family of protein-misfolding diseases called tauopathies, which include frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP-17), Pick’s disease, progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), and chronic traumatic encephalopathy [7].