Clinical management of PCOS should include rigorous lifestyle modifications, insulin therapy, and drug treatments that promote insulin sensitization (such as metformin) and insulin secretion (such as glibenclamide), dipeptidyl peptidase-4 inhibitors, sodium glucose cotransporter 2 inhibitors [100], and antihyperlipidemic therapy [101]. This evidence concerns the gene SLC5A2 and polycystic ovary syndrome.