Kim et al. reported that KIR3DL1+NK cells in HLA-Bw4 homozygous healthy individuals were more responsive to autologous target cells than in HLA-Bw6 homozygous healthy donors (46), while the functionality of KIR3DL1+NK cells did not differ in HLA-Bw4 carriers and HLA-Bw6 homozygous individuals in HIV-1 infection (47). This evidence concerns the gene KIR3DL1 and HIV-1 infection.