It has, therefore, been suggested that KIR3DL1-positive CD8 T cells function poorly in HIV-1-infected individuals displaying homozygosity for Bw4. By contrast, Bw4 homozygosity may strengthen the functions of KIR3DL1-negative CD8 T cells, resulting in enhanced immune surveillance and playing a predominant role in protection against HIV-1 infection. This evidence concerns the gene CD8A and HIV-1 infection.