Since Smad7 stability and expression is mostly regulated by post-transcriptional mechanisms, which enhance Smad7 acetylation (7), we examined whether changes in Sirt1 activation following treatment of normal or IBD LPMC with Ex527 or Cay 10591, respectively, affected the status of Smad7 acetylation/ubiquitination. The gene discussed is SIRT1; the disease is inflammatory bowel disease.