In agreement with previous studies demonstrating decreased tissue inflammation and inflammatory cytokine secretion in Flii-deficient mice (24, 32), OVA-induced AD-like skin lesions of Flii+/− mice showed a reduced inflammatory response marked by significantly increased anti-inflammatory IL-10 secretion as well as significantly increased IFN-γ and significantly reduced IL-4 levels. This evidence concerns the gene IL4 and Alzheimer disease.