Flii homozygous (Flii−/−) mice are embryonic lethal (26); therefore, using the OVA-induced AD-like skin mouse model, the severity of OVA-induced AD-like lesions was determined in response to different Flii gene levels in Flii heterozygous (Flii+/−), normal (Flii+/+), and Flii transgenic (FliiTg/Tg) mice. Here, FLII is linked to Alzheimer disease.