Examining the levels of cytokines and chemokines produced in AD-like lesional skin of Flii+/−, wild-type, and FliiTg/Tg mice revealed decreased IFN-γ levels in FliiTg/Tg mice suggestive of Th2 immune responses, while Flii+/− had increased IFN-γ levels and decreased clinical AD severity suggestive of potential Flii effect on IgE synthesis, however, this is yet to be investigated. The gene discussed is IGHE; the disease is Alzheimer disease.