Other studies have also revealed important regulatory functions of IRF9–STAT2, which includes gene expression of retinoic acid-induced gene G (65), prolonging the ISGF3-like transcriptional activity (66) and drives the IL-6 expression (67)—a proinflammatory cytokine whose elevated serum level is associated with various cancers (68). The gene discussed is IRF9; the disease is cancer.