These two cytokines are also critical in MM-related immunosuppression, since IL-10 has potent immunosuppressive ability by inhibiting production of pro-inflammatory interferon-γ (IFN-γ) and TNF-α in immune effector cells (95), and IL-6 has been linked to impaired NK cell activity (96). The gene discussed is IFNG; the disease is Miyoshi myopathy.