IGHA1 and B-cell chronic lymphocytic leukemia: This overrepresentation of IgA1/2 isotypes in non-malignant CLL repertoires was not an artifact of the depletion of the IGHV-J genes associated with the leukemic clones as the enrichment of IgA1/2 was maintained (p-value <0.0005) even after the removal of the same IGHV-J gene combinations from the healthy repertoires (Figure S8 in Supplementary Material).